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X-ray diffraction or XRD is an analytical tool that utilizes X-rays to study ordered structures such as crystalline organic and inorganic samples, polycrystalline materials, proteins, carbohydrates, and drugs.
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Related Experiment Video

Updated: May 23, 2026

Sample Preparation and Transfer Protocol for In-Vacuum Long-Wavelength Crystallography on Beamline I23 at Diamond Light Source
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I19, the small-molecule single-crystal diffraction beamline at Diamond Light Source.

Harriott Nowell1, Sarah A Barnett, Kirsten E Christensen

  • 1Diamond Light Source, Harwell Science and Innovation Campus, Didcot, Oxfordshire OX11 0DE, UK.

Journal of Synchrotron Radiation
|April 20, 2012
PubMed
Summary

The I19 beamline at Diamond Light Source offers high-flux, tunable X-ray diffraction for small molecules. It supports diverse studies, including challenging crystal structures and non-ambient conditions.

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Area of Science:

  • Crystallography
  • Materials Science
  • Chemistry

Background:

  • The I19 beamline at Diamond Light Source has been operational for over three years.
  • It is a high-flux, tunable-wavelength beamline designed for small-molecule single-crystal X-ray diffraction.

Purpose of the Study:

  • To describe the key details and capabilities of the I19 beamline.
  • To highlight the diverse range of scientific applications supported by the beamline.

Main Methods:

  • Single-crystal X-ray diffraction using a high-flux, tunable-wavelength beamline.
  • Utilizing various sample environments for non-ambient crystallography (high pressure, variable temperature).
  • Analysis of diffuse scattering for structural characterization.

Main Results:

  • Successful structure determination from small and weakly diffracting crystals.
  • Support for a wide array of experiments including high-pressure studies, metastable species, and gas exchange in porous materials.
  • Demonstration of the beamline's versatility through selected scientific highlights.

Conclusions:

  • The I19 beamline is a versatile and powerful facility for small-molecule crystallography.
  • It enables cutting-edge research across various scientific disciplines by accommodating diverse experimental conditions and sample types.