Association between polymyalgia rheumatica and vascular disease: a systematic review

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Adam T Hancock1, Christian D Mallen, John Belcher

  • 1Arthritis UK Primary Care Centre, Keele University, Stoke-on-Trent, UK. athancock@doctors.org.uk

Arthritis Care & Research
|April 20, 2012
PubMed
Abstract

Insights

Polymyalgia rheumatica (PMR) may increase vascular disease risk, similar to other inflammatory conditions. Further research is needed to confirm this link and guide patient screening for cardiovascular issues.

Area of Science:

  • Rheumatology
  • Cardiovascular Medicine
  • Epidemiology

Background:

  • Polymyalgia rheumatica (PMR) is an inflammatory condition.
  • The association between PMR and vascular disease requires further investigation.

Purpose of the Study:

  • To systematically review and evaluate studies on the link between polymyalgia rheumatica and vascular disease.

Main Methods:

  • Searched Medline, Embase, CINAHL, and Cochrane databases up to September 2010.
  • Included observational studies of patients with isolated PMR reporting vascular outcomes.
  • Assessed data extraction and article quality.

Main Results:

  • Eight articles from 7 unique studies were reviewed.
  • Four studies found a significant positive association between PMR and vascular disease.
  • Study design (retrospective vs. prospective) influenced results, with retrospective studies showing significant associations.

Conclusions:

  • Evidence suggests polymyalgia rheumatica may be associated with increased vascular disease risk.
  • Further studies are needed to quantify this risk.
  • Recommendations for cardiovascular screening in PMR patients are warranted.

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