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Key observations from the NHLBI Asthma Clinical Research Network
Stanley J Szefler1, Vernon M Chinchilli, Elliot Israel
1Department of Pediatrics, National Jewish Health and University of Colorado Denver, School of Medicine, Denver, Colorado 80206, USA. szeflers@njhealth.org
Thorax
|April 20, 2012
Summary
The National Heart, Lung, and Blood Institute Asthma Clinical Research Network (ACRN) concluded 20 years of asthma research. Its trials significantly advanced understanding and treatment of asthma management.
Area of Science:
- Pulmonology
- Clinical Trials
- Pharmacology
Background:
- The National Heart, Lung, and Blood Institute (NHLBI) Asthma Clinical Research Network (ACRN) operated for 20 years.
- Its mission was to conduct controlled clinical trials for asthma treatment and disseminate findings.
Purpose of the Study:
- To review major research observations from the ACRN.
- To highlight the impact of ACRN findings on current asthma management.
Main Methods:
- The ACRN conducted 15 major multicentre clinical trials.
- Data from all trials are publicly available through NHLBI BioLINCC.
- Research focused on evaluating existing and novel asthma therapies.
Main Results:
- Significant insights were gained into inhaled corticosteroids, ß-agonists, leukotriene receptor antagonists, and novel agents like tiotropium.
- Pioneered studies on drug response variability, treatment response predictors, and pharmacogenetics.
- ACRN findings have demonstrably impacted current asthma treatment guidelines.
Conclusions:
- The ACRN provided crucial advancements in understanding and treating asthma over two decades.
- Its legacy includes improved therapeutic strategies and a deeper understanding of individual treatment responses.
- The network's contributions continue to shape the landscape of asthma care.
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