Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Testosterone: Functions and Regulation

Testosterone: Functions and Regulation

The intricate hormonal interplay essential for male reproductive health begins with the release of gonadotropin-releasing hormone (GnRH) by the hypothalamus. This hormone prompts the pituitary gland to secrete follicle-stimulating hormone (FSH) and luteinizing hormone (LH). LH targets the Leydig cells in the testes, stimulating them to produce and release testosterone. In concert with testosterone, FSH acts on the Sertoli cells within the seminiferous tubules to facilitate the release of...

The Effect of Aging on Tissues

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...

Aging

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...

Menopause

Menopause

Menopause, a natural biological process marking the end of a woman's fertility, typically occurs between the fifth and sixth decade of life. This phase is characterized by the exhaustion of the ovarian follicle pool, leading to less responsive ovaries despite the high levels of Follicle Stimulating Hormone (FSH) and Luteinizing Hormone (LH). The consequential decrease in estrogen production results in symptoms like hot flashes, heavy sweating, headaches, hair loss, muscle pains, vaginal...

Pharmacodynamics in Geriatric Patients: Effects of Age

Pharmacodynamics in Geriatric Patients: Effects of Age

Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...

Disorders of the Male Reproductive System

Disorders of the Male Reproductive System

Men's health issues are increasingly recognized as significant, with several conditions posing common threats. Among these, testicular cancer is especially prevalent in younger men, particularly those aged 20 to 35 years. The disease often manifests as a painless mass in the testicles, sometimes accompanied by a sensation of heaviness or a dull ache.
Prostate disorders are another major concern. These conditions can impair urinary flow due to the prostate's location around the urethra. Symptoms...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

VEGF inhibitor-induced vascular dysfunction involves redox-sensitive PARP activation and SIRT1 disruption.

Experimental physiology·2026

Same author

Estrogen treatment restores perivascular adipose tissue -mediated anticontractile effect via NOX4-dependent hydrogen peroxide signaling in ovariectomized hypertensive rats.

Journal of hypertension·2026

Same author

Renal-vascular axis: unmasking its role in vascular endothelial growth factor-inhibitor vascular toxicity in cancer patients.

British journal of pharmacology·2026

Same author

Nebivolol restores the anticontractile effect of mesenteric perivascular adipose tissue lost due to obesity.

European journal of pharmacology·2025

Same author

Ethanol-induced dysfunction of the mesenteric perivascular adipose tissue is driven by mineralocorticoid receptors.

Pflugers Archiv : European journal of physiology·2025

Same author

The role of aldosterone on the endothelial dysfunction induced by female hormone deficiency.

Molecular and cellular endocrinology·2025

Search research articles

Related Experiment Video

Updated: May 23, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Testosterone and vascular function in aging.

Rhéure A M Lopes¹, Karla B Neves, Fernando S Carneiro

¹Department of Pharmacology, Medical School of Ribeirao Preto, Ribeirao Preto São Paulo, Brazil.

Frontiers in Physiology

|April 20, 2012

Summary

This summary is machine-generated.

Testosterone influences vascular function and aging. Declining testosterone levels with age may contribute to cardiovascular disease, though testosterone

Keywords:

aging cardiovascular disease testosterone vascular function

More Related Videos

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Related Experiment Videos

Last Updated: May 23, 2026

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues

Published on: June 3, 2019

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Improving Strength, Power, Muscle Aerobic Capacity, and Glucose Tolerance through Short-term Progressive Strength Training Among Elderly People

Published on: July 5, 2017

Area of Science:

Endocrinology
Cardiovascular Biology
Gerontology

Background:

Androgen receptors are present in vascular cells, mediating testosterone's effects.
Testosterone impacts vascular function through genomic and non-genomic pathways.
Aging is associated with both declining testosterone and vascular dysfunction.

Purpose of the Study:

To review the interplay between aging and testosterone levels.
To discuss testosterone's vascular actions and implications for vascular aging.
To address testosterone's renal effects and potential therapeutic use in elderly vascular dysfunction.

Main Methods:

Literature review of experimental evidence on testosterone, aging, and vascular function.
Analysis of studies on androgen receptor signaling in cardiovascular tissues.
Examination of the relationship between testosterone levels and age-related diseases.

Main Results:

Testosterone can negatively affect vascular function by promoting inflammation and arterial thickening.
Testosterone modulates nitric oxide (NO) synthesis, impacting endothelial function.
Low testosterone levels in aging may contribute to cardiovascular dysfunction.

Conclusions:

Testosterone has complex roles in vascular health, with potential benefits and detriments.
Understanding testosterone's impact is crucial for managing vascular aging and related diseases.
Further research is needed on testosterone's therapeutic potential in elderly cardiovascular health.