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Updated: May 23, 2026

An Experimental Model to Study Tuberculosis-Malaria Coinfection upon Natural Transmission of Mycobacterium tuberculosis and Plasmodium berghei
Published on: February 17, 2014
[Two cases of pulmonary tuberculosis with an intra-familial transmission route]
Keiko Mitaka1, Takayuki Honda, Kazuhiro Fukasawa
1Department of Pulmonary Medicine, Yamanashi Prefectural Central Hospital, 1-1-1, Fujimi, Kofu-shi, Yamanashi 400-8506, Japan. k-mitaka0801@ych.pref.yamanashi.jp
Abstract:
Two patients with smear-positive adult-type pulmonary tuberculosis (TB) were admitted to our hospital. The patients in case 1 and case 2 were a 33-year-old woman and a 33-year-old man, respectively. None of the patients' family members had any apparent symptom indicating TB. However, the father of patient 1 was found to have recurrent TB with a positive smear in the contact investigation. The mother of patient 2 was then admitted to a hospital with acute respiratory failure caused by recurrence of TB. Her sputum sample also turned out to be smear-positive. Restriction fragment length polymorphism (RFLP) analysis of the isolates revealed identical DNA patterns in each pair of family members. These cases were typical examples of intra-familial infections involving young adults and their parents. This route of transmission is still important in areas with low prevalence of the disease.
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