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Updated: May 23, 2026

Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
Published on: July 27, 2022
The in vitro and in vivo study on self-nanoemulsifying drug delivery system (SNEDDS) based on insulin-phospholipid
Qianyu Zhang1, Na He, Li Zhang
1Key Laboratory of Drug Targeting and Drug Delivery Systems, West China School of Pharmacy, Sichuan University, No. 17, Block 3, Southern Renmin Road, Chengdu 610041, Sichuan, China.
Abstract:
Self-nanoemulsifying drug delivery system (SNEDDS) was developed to enhance the absorption of insulin after oral administration, where insulin was complexed with phospholipid to achieve a better liposolubility in the form of insulin-phospholipid complex (IPC). IPC was formulated into the oil phase of SNEDDS by solvent-evaporation method. The formula of IPC-SNEDDS was optimized and characterized. Data showed that SNEDDS as a drug vehicle did not exhibit an obvious inhibition over MDCK cells, and it can facilitate the transport of IPC across MDCK cell monolayer. IPC-SNEDDS could enhance the absorption of insulin after oral administration and yielded a pronounced hypoglycemic effect on diabetic Wistar rats. All these suggested that IPC-SNEDDS has a great potential for oral delivery of insulin.
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