Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: May 23, 2026

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues
11:31

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Published on: August 28, 2014

Electrosensitive polyacrylic acid/fibrin hydrogel facilitates cell seeding and alignment.

Nastaran Rahimi1, Daniel G Molin, Thomas J Cleij

  • 1Department of Physiology, Maastricht University, 6200 MD Maastricht, The Netherlands.

Biomacromolecules
|April 21, 2012
PubMed
Summary

This study introduces a smart hydrogel that uses electrical stimulation to mechanically guide cell alignment and distribution in tissue engineering. The electroresponsive material acts as a pump, enhancing cell infiltration for constructs like vascular grafts.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fungal Spore Detection of the Gray Mold Crop Disease: Imprinted-Polymer Thermometric Sensing Platform for the Real-Time Monitoring of <i>Botrytis cinerea</i>.

Journal of agricultural and food chemistry·2026
Same author

Colorimetric sensing of sinapic acid in mustard seeds based on DES-modified imprinted polymers and Cu(II) complexation.

Food chemistry·2026
Same author

Detection of Anti-<i>Mycobacterium leprae</i> Antibodies in Leprosy Contacts Using a Label-Free Approach with the Heat-Transfer Method.

ACS sensors·2026
Same author

Biosensor-Based Platforms for the Detection and Screening of <i>Mycobacterium leprae</i> Infection.

ACS infectious diseases·2026
Same author

Mono- and bimetallic homo- and heterodinuclear Pd and Pt complexes bridged by diphosphines: synthesis, characterisation and cytotoxicity.

Dalton transactions (Cambridge, England : 2003)·2025
Same author

Drug-Checking with Molecularly Imprinted Polymers: Addressing Xylazine-Contaminated Fentanyl.

ACS sensors·2025

Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Biomedical Engineering

Background:

  • Three-dimensional cell culture is crucial for tissue-engineered constructs, such as vascular grafts.
  • Guiding cell distribution and patterning is essential for construct functionality.
  • Electroresponsive polymers can convert electrical stimuli into mechanical forces.

Purpose of the Study:

  • To develop an electrosensitive, biocompatible hydrogel for mechanical cell stimulation.
  • To investigate the potential of this hydrogel as a smart device for tissue engineering.

Main Methods:

  • Hydrogel fabrication using acrylic acid and fibrin.
  • Characterization of hydrogel structural properties (FTIR-ATR, SEM, prosimetry, swelling).
  • Evaluation of porcine smooth muscle cell (pSMC) distribution and alignment using two-photon laser scanning microscopy.

More Related Videos

Preparation of DNA-crosslinked Polyacrylamide Hydrogels
09:06

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels
10:19

Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels

Published on: August 10, 2010

Related Experiment Videos

Last Updated: May 23, 2026

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues
11:31

Preparation of Hydroxy-PAAm Hydrogels for Decoupling the Effects of Mechanotransduction Cues

Published on: August 28, 2014

Preparation of DNA-crosslinked Polyacrylamide Hydrogels
09:06

Preparation of DNA-crosslinked Polyacrylamide Hydrogels

Published on: August 27, 2014

Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels
10:19

Studying the Effects of Matrix Stiffness on Cellular Function using Acrylamide-based Hydrogels

Published on: August 10, 2010

Main Results:

  • Pulsatile electrical stimulation of hydrogels induced dynamic swelling and deswelling.
  • Enhanced pSMC penetration and alignment were observed after 2 hours of electrical stimulation compared to static controls.
  • The hydrogel functioned as a mechanical pump, directing cell alignment and infiltration.

Conclusions:

  • The developed hydrogel is an effective electrosensitive and biocompatible smart device.
  • Electrical stimulation can mechanically guide cell alignment and distribution in tissue engineering.
  • This technology holds promise for creating advanced tissue-engineered constructs, including vascular grafts.