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Updated: May 23, 2026

Preparation, Purification, and Characterization of Lanthanide Complexes for Use as Contrast Agents for Magnetic Resonance Imaging
Published on: July 21, 2011
2,6-Bis(5-(2,2-dimethylpropyl)-1H-pyrazol-3-yl)pyridine as a ligand for efficient actinide(III)/lanthanide(III)
Antje Bremer1, Christian M Ruff, Denise Girnt
1Institut für Nukleare Entsorgung, Karlsruher Institut für Technologie, P.O. Box 3640, 76021 Karlsruhe, Germany.
Abstract:
The N-donor complexing ligand 2,6-bis(5-(2,2-dimethylpropyl)-1H-pyrazol-3-yl)pyridine (C5-BPP) was synthesized and screened as an extracting agent selective for trivalent actinide cations over lanthanides. C5-BPP extracts Am(III) from up to 1 mol/L HNO(3) with a separation factor over Eu(III) of approximately 100. Due to its good performance as an extracting agent, the complexation of trivalent actinides and lanthanides with C5-BPP was studied. The solid-state compounds [Ln(C5-BPP)(NO(3))(3)(DMF)] (Ln = Sm(III), Eu(III)) were synthesized, fully characterized, and compared to the solution structure of the Am(III) 1:1 complex [Am(C5-BPP)(NO(3))(3)]. The high stability constant of log β(3) = 14.8 ± 0.4 determined for the Cm(III) 1:3 complex is in line with C5-BPP's high distribution ratios for Am(III) observed in extraction experiments.
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