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Measuring and Modeling Contractile Drying in Human Stratum Corneum
Published on: March 1, 2017
Stratum corneum dysfunction in dandruff
G A Turner1, M Hoptroff, C R Harding
1Unilever Research & Development Port Sunlight, Bebington, Merseyside, UK. graham.turner@unilever.com
International Journal of Cosmetic Science
|April 21, 2012
Summary
Dandruff involves a flaky scalp, influenced by Malassezia yeast and impaired skin barrier function. Improving scalp stratum corneum integrity alongside antifungal action may effectively treat dandruff.
Area of Science:
- Dermatology
- Microbiology
- Cosmetic Science
Background:
- Dandruff affects up to 50% of the population, characterized by scalp flaking and itching.
- Its multifactorial causes include Malassezia yeast, sebum, and individual susceptibility.
- A healthy stratum corneum (SC) is crucial for scalp barrier function and protection.
Purpose of the Study:
- To explore the role of stratum corneum integrity in dandruff development.
- To investigate the relationship between Malassezia and SC barrier disruption.
- To propose therapeutic strategies targeting SC integrity and Malassezia.
Main Methods:
- Review of scientific literature on dandruff etiology and scalp barrier function.
- Analysis of the structural and functional characteristics of the stratum corneum in dandruff.
- Correlation of Malassezia presence with SC barrier defects and clinical symptoms.
Main Results:
- Dandruff scalps exhibit depleted and disorganized structural lipids, indicating a weakened barrier.
- Elevated transepidermal water loss and increased susceptibility to irritants are observed in dandruff.
- Malassezia alone is not sufficient; SC disruption may enhance susceptibility to its metabolites.
Conclusions:
- Disruption of the scalp's stratum corneum may contribute to dandruff generation.
- Therapeutic approaches should focus on improving SC integrity and providing antifungal activity.
- Cosmetic products enhancing SC integrity could offer beneficial dandruff treatment.
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