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Survival analysis of pediatric dialysis patients in Taiwan

Hsin-Hung Lin1, Ching-Wei Tsai, Pao-Hsuan Lin

  • 1The Kidney Institute and Division of Nephrology, China Medical University Hospital, Taichung, Taiwan.

Nephrology (Carlton, Vic.)
|April 21, 2012
PubMed

Insights

Long-term survival for Taiwanese children with end-stage renal disease (ESRD) shows no significant difference between haemodialysis (HD) and peritoneal dialysis (PD). Older children experienced better survival outcomes than younger ones.

Area of Science:

  • Nephrology
  • Pediatric Nephrology
  • Renal Replacement Therapy

Background:

  • Long-term survival data for pediatric end-stage renal disease (ESRD) patients in Taiwan is previously unreported.
  • Understanding survival trends and mortality causes is crucial for improving pediatric ESRD care.

Purpose of the Study:

  • To determine the long-term survival rates of pediatric patients with ESRD in Taiwan.
  • To analyze mortality hazards and identify the primary causes of death in children undergoing dialysis.

Main Methods:

  • Retrospective analysis of pediatric ESRD patients (≤19 years) from the Taiwan Renal Registry (1995-2004).
  • Inclusion of 319 hemodialysis (HD) and 156 peritoneal dialysis (PD) patients.
  • Multivariate Cox proportional-hazards model used, stratifying by dialysis modality and adjusting for age, sex, and comorbidities.

Main Results:

  • Overall 1-, 5-, and 10-year survival rates were comparable between PD (98.1%, 88.0%, 68.4%) and HD (96.9%, 87.3%, 78.5%) patients (P=0.4878).
  • Youngest children (0-4 years) faced significantly higher mortality risk compared to older adolescents (15-19 years).
  • Infection, cardiovascular disease, and cerebrovascular disease were the leading causes of death.

Conclusions:

  • No significant difference in long-term survival between HD and PD treatments for pediatric ESRD patients in Taiwan.
  • Age is a significant factor, with younger children exhibiting poorer survival rates compared to older pediatric patients.
Abstract

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