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Updated: May 23, 2026

Compact Quantum Dots for Single-molecule Imaging
Published on: October 9, 2012
Hybrid semiconducting polymer dot-quantum dot with narrow-band emission, near-infrared fluorescence, and high
Yang-Hsiang Chan1, Fangmao Ye, Maria Elena Gallina
1Department of Chemistry, University of Washington, Seattle, Washington 98195, USA.
Abstract:
This communication describes a new class of semiconducting polymer nanoparticle-quantum dot hybrid with high brightness, narrow emission, near-IR fluorescence, and excellent cellular targeting capability. Using this approach, we circumvented the current difficulty with obtaining narrow-band-emitting and near-IR-fluorescing semiconducting polymer nanoparticles while combining the advantages of both semiconducting polymer nanoparticles and quantum dots. We further demonstrated the use of this new class of hybrid nanomaterial for effective and specific cellular and subcellular labeling without any noticeable nonspecific binding. This hybrid nanomaterial is anticipated to find use in a variety of in vitro and in vivo biological applications.
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