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Related Concept Videos

Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Roller Microneedle Combined with Tranexamic Acid Solution in Treating Melasma
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Published on: January 19, 2024

Acquired patch-type blue nevus with overlying vitiligo: a case report.

Peng Wang1, Yan Cheng, Hanjun Yang

  • 1Department of Dermatovenereology, West China Hospital, Sichuan University, 610041 Chengdu, China.

International Journal of Dermatology
|April 21, 2012
PubMed
Summary

This study reports a rare case of patch-type blue nevus, a skin condition causing blue-gray patches, co-occurring with vitiligo. This unusual combination of dermal melanocytosis and depigmentation has not been previously documented.

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Area of Science:

  • Dermatology
  • Pathology
  • Genetics

Background:

  • Blue nevi encompass congenital and acquired dermal melanocytoses, presenting a blue-gray skin hue.
  • Common blue nevus and cellular blue nevus are prevalent subtypes, while patch-type blue nevus is infrequent.

Observation:

  • A 77-year-old Chinese male presented with a 6x8 cm non-palpable blue patch on his left scalp, overlaid by a depigmented patch.
  • Histological analysis revealed numerous spindled, bipolar dendritic melanocytes in the upper reticular dermis, with no epidermal melanocytes.

Findings:

  • Immunohistochemistry confirmed melanocytes positive for S-100 and HMB-45.
  • The diagnosis was established as patch-type blue nevus with superimposed vitiligo.

Implications:

  • This case highlights an exceptionally rare presentation of patch-type blue nevus coexisting with vitiligo.
  • The findings expand the clinical spectrum of blue nevi and associated pigmentary disorders.