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Immunogenicity and efficacy of an anthrax/plague DNA fusion vaccine in a mouse model
Mark T Albrecht1, Jim E Eyles, Les W Baillie
1Biological Defense Research Directorate, Naval Medical Research Center, Fort Detrick, MD, USA.
Abstract:
The efficacy of multi-agent DNA vaccines consisting of a truncated gene encoding Bacillus anthracis lethal factor (LFn) fused to either Yersinia pestis V antigen (V) or Y . pestis F1 was evaluated. A/J mice were immunized by gene gun and developed predominantly IgG1 responses that were fully protective against a lethal aerosolized B. anthracis spore challenge but required the presence of an additional DNA vaccine expressing anthrax protective antigen to boost survival against aerosolized Y. pestis.
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