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Updated: May 23, 2026

Brain Ventricular Microinjections of Lipopolysaccharide into Larval Zebrafish to Assess Neuroinflammation and Neurotoxicity
Published on: August 23, 2022
Inflammation and clinical presentation in neurodegenerative disease: a volatile relationship
Brianne Magouirk Bettcher1, Joel H Kramer
1Neurology Department, Memory and Aging Center, University of California, San Francisco, CA 94143-1207, USA. bbettcher@memory.ucsf.edu
Abstract:
A proposed immune mechanism that potentially modifies or exacerbates neurodegenerative disease presentation in older adults has received considerable attention in the past decade, with recent studies demonstrating a strong link between pro-inflammatory markers and neurodegeneration. The overarching aim of the following review is to synthesize recent research that supports a possible relationship between inflammation and clinical features of neurodegenerative diseases, including risk of development, cognitive and clinical correlates, and progression of the specified diseases. Specific emphasis is placed on providing a temporal context for the association between inflammation and neurodegeneration.
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