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Related Concept Videos

Cardiomyopathy III: Hypertrophic Cardiomyopathy01:29

Cardiomyopathy III: Hypertrophic Cardiomyopathy

Hypertrophic cardiomyopathy, or HCM, is an autosomal dominant genetic disorder characterized by asymmetric left ventricular hypertrophy without ventricular dilation. It is more common in men and is typically diagnosed in young, athletic adults.EtiologyHCM is primarily genetic and is caused by mutations in genes encoding sarcomeric proteins. Researchers have identified over 1400 mutations across at least 11 different genes. Among these, the most frequently occurring mutations are found in the...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
Imbalances in Cardiac Output01:26

Imbalances in Cardiac Output

The heart's primary function is to pump blood throughout the body, maintaining a balance between blood sent out (cardiac output) and blood returning (venous return). If this balance is disrupted, it can result in congestive heart failure (CHF), a severe condition where the heart becomes an inefficient pump, leading to inadequate blood circulation.
CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Mitral Valve Prolapse II: Assessment and Management01:22

Mitral Valve Prolapse II: Assessment and Management

IntroductionA range of clinical features characterizes Mitral Valve Prolapse (MVP), but it is important to note that many individuals with MVP are asymptomatic and may remain so throughout their lives. For those who do exhibit symptoms, the following are the key clinical features:Palpitations: This is a common symptom where individuals feel an irregular or rapid heartbeat. Palpitations in MVP are often due to arrhythmias such as premature ventricular contractions or supraventricular tachycardia.

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Related Experiment Video

Updated: May 23, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Neurological comorbidity affects prognosis in left ventricular hypertrabeculation/noncompaction.

Claudia Stöllberger1, Gerhard Blazek, Christian Wegner

  • 1Second Medical Department, Krankenanstalt Rudolfstiftung, Vienna, Austria. claudia.stoellberger@chello.at

Heart & Lung : the Journal of Critical Care
|April 21, 2012
PubMed
Summary

Left ventricular hypertrabeculation/noncompaction (LVHT) with neuromuscular disorders (NMDs) has a worse prognosis. Neurological investigation is recommended for LVHT patients to identify NMDs and guide management for improved outcomes.

Related Experiment Videos

Last Updated: May 23, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

Area of Science:

  • Cardiology
  • Neurology
  • Genetics

Background:

  • Left ventricular hypertrabeculation/noncompaction (LVHT) is a cardiac abnormality often linked to neuromuscular disorders (NMDs).
  • The prognostic implications of co-existing NMDs in LVHT patients are not well understood.

Purpose of the Study:

  • To compare baseline characteristics and prognoses of LVHT patients with and without NMDs.
  • To determine if neurological investigation impacts LVHT patient outcomes.

Main Methods:

  • Prospective observational study of 172 LVHT patients diagnosed between 1995-2011.
  • Baseline cardiologic examination and optional neurological investigation.
  • Follow-up via telephone contact in 2011.

Main Results:

  • Of 172 LVHT patients, 123 underwent neurological investigation, revealing specific NMDs in 25 and unknown NMDs in 79.
  • No significant differences in baseline characteristics were observed between LVHT patients with and without NMDs.
  • Mortality was 4.84%/year over a median follow-up of 64 months; no deaths occurred in the NMD-negative group.

Conclusions:

  • The presence of NMDs significantly influences the prognosis of LVHT patients.
  • Neurological evaluation is crucial upon LVHT diagnosis.
  • LVHT patients with NMDs require close monitoring for arrhythmias and heart failure, with consideration for cardiac electronic devices.