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Modic changes: prevalence, distribution patterns, and association with age in white men.

Yue Wang¹, Tapio Videman, Michele C Battié

¹Faculty of Rehabilitation Medicine, University of Alberta, 8205 114 St, 3-44 Corbett Hall, Edmonton, AB, Canada T6G 2G4.

The Spine Journal : Official Journal of the North American Spine Society

|April 21, 2012

Summary

Modic changes (MCs) are common in middle-aged men

Related Experiment Videos

Area of Science:

Spine imaging and epidemiology
Degenerative disc disease research
Musculoskeletal health studies

Background:

Modic changes (MCs) are increasingly recognized in spine research.
Epidemiological data on MCs in the general population is limited.
Understanding MC prevalence provides clinical reference.

Purpose of the Study:

To determine the prevalence and distribution of Modic changes in the lumbosacral spine.
To investigate the association between Modic changes and age in men.
To provide population-based data on Modic changes.

Main Methods:

Epidemiological analysis of lumbar spine magnetic resonance images (MRIs).
Inclusion of 561 male twin subjects representative of the Finnish population.
Evaluation of 11 lumbar end plates (L1-S1) for Modic changes (Types 1, 2, 3, and mixed).

Main Results:

Modic changes found in 55.6% of individuals and 13.5% of end plates.
Type 2 MCs were most prevalent (64.2%), followed by Type 1 (16.0%) and Mixed (18.1%).
MCs were more common in the lower lumbar region, often affecting opposing end plates, and increased with age.

Conclusions:

Modic changes are prevalent in middle-aged men, predominantly Type 2.
MCs are common in the lower lumbar spine, affecting adjacent end plates.
Age is significantly associated with the presence and size of Modic changes.