Related Experiment Videos
Excess mortality among the elderly in 12 European countries, February and March 2012
A Mazick1, B Gergonne, J Nielsen
1Statens Serum Institut, Copenhagen, Denmark. maz@ssi.dk
Summary
Excess elderly deaths in 12 European countries during February-March 2012 suggest a significant influenza A(H3N2) impact. This differs from recent seasons, possibly exacerbated by cold weather.
Area of Science:
- Epidemiology
- Virology
- Public Health
Background:
- Excess mortality in the elderly population is a key indicator of public health impact during winter seasons.
- Recent influenza seasons (pandemic and post-pandemic) showed different patterns of mortality.
- European countries conduct weekly all-cause mortality monitoring.
Purpose of the Study:
- To analyze excess mortality trends in elderly populations across 12 European countries in early 2012.
- To investigate the potential drivers of observed excess deaths, specifically influenza A(H3N2) and cold weather.
- To compare the 2012 influenza season's impact with previous pandemic and post-pandemic periods.
Main Methods:
- Utilized weekly all-cause mortality data from 12 European countries.
- Focused on the elderly demographic during February and March 2012.
- Correlated mortality data with influenza virus surveillance and meteorological data.
Main Results:
- Observed excess deaths among the elderly in 12 European countries during February-March 2012.
- Preliminary data suggest the impact of influenza A(H3N2) virus.
- Potential contribution of a cold snap to the increased mortality was noted.
Conclusions:
- The 2012 winter season exhibited a distinct mortality pattern in European elderly populations.
- Influenza A(H3N2) resurgence is a likely primary cause of the excess elderly mortality.
- Combined effects of influenza and cold weather warrant further investigation for public health preparedness.
Related Concept Videos
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion
In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...
Drug Dosing: Geriatric Patients
Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
The Effect of Aging on Tissues
Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Distribution
Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are not...