Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Tissue Renewal without Stem Cells01:23

Tissue Renewal without Stem Cells

After cellular or tissue damage, the resident stem cells present in the human body can locally repair and regenerate the damaged tissue or organ. However, even though some tissues do not have stem cells, they can repair and regenerate with the help of pre-existing cells. For example, beta cells of the pancreas and hepatocytes of the liver can divide to renew and regenerate the tissue. Here, both cell division and cell death are well regulated by homeostasis.
However, failure of such a system...
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell types that...
Whole Body Regeneration01:33

Whole Body Regeneration

Regeneration is the process of restoring injured or lost tissues, organs, or body parts. While simpler organisms generally show greater ability to regenerate their whole body, few complex animals show similarly exceptional regeneration. For example, planarian flatworms have a unique regenerative potential making them a popular study organism among biologists to understand the mechanisms of whole body regeneration. Other organisms, such as hydra, also show extreme regeneration potential; even...
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

"Pattern regulation in epimorphic fields", aka the polar coordinate model.

Developmental biology·2025
Same author

Ectopic expression of HNF4α in Het1A cells induces an invasive phenotype.

Differentiation; research in biological diversity·2023
Same author

What is a stem cell?

Wiley interdisciplinary reviews. Developmental biology·2018
Same author

Transformation of jaw muscle satellite cells to cardiomyocytes.

Differentiation; research in biological diversity·2016
Same author

Hnf4α is a key gene that can generate columnar metaplasia in oesophageal epithelium.

Differentiation; research in biological diversity·2016
Same author

Turning One Cell Type into Another.

Current topics in developmental biology·2016

Related Experiment Video

Updated: May 23, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Alternative cells for regeneration.

Jonathan M W Slack1

  • 1Stem Cell Institute, University of Minnesota, Minneapolis, MN 55455, USA. slack017@umn.edu

Developmental Cell
|April 21, 2012
PubMed
Summary

Fish fin regeneration typically involves bone rebuilding bone. This study reveals that bony rays can regenerate from an alternative cell source when bone is absent, offering new insights into regenerative processes.

Area of Science:

  • Developmental Biology
  • Regenerative Medicine
  • Comparative Physiology

Background:

  • Fish fin regeneration is a model for studying tissue repair.
  • Bone regeneration usually occurs from existing bone tissue.
  • The cellular mechanisms underlying fin ray regeneration in the absence of bone are not well understood.

Discussion:

  • This research investigates the cellular origins of regenerating fin rays in fish lacking bone.
  • The study by Singh et al. (2012) challenges the conventional understanding of bone regeneration.
  • Alternative cell sources are identified for the regeneration of bony fin rays.

Key Insights:

  • Fin bony rays can regenerate from a non-bone cell source.
  • This finding expands our knowledge of developmental plasticity in vertebrates.

More Related Videos

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment
10:16

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment

Published on: March 28, 2022

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

Related Experiment Videos

Last Updated: May 23, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment
10:16

Primary Cell Cultures to Study the Regeneration Potential of Murine Müller Glia after MicroRNA Treatment

Published on: March 28, 2022

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain
11:27

Growing Neural Stem Cells from Conventional and Nonconventional Regions of the Adult Rodent Brain

Published on: November 18, 2013

  • The study highlights the potential for novel regenerative strategies.

    • Outlook:

    • Further research could explore the specific cell types and signaling pathways involved.
    • Understanding these alternative regeneration mechanisms may inform therapeutic approaches in humans.
    • This work opens new avenues for research in tissue regeneration and evolution.