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Updated: May 23, 2026

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Published on: August 13, 2019
Phytoestrogens for menopausal symptoms: a review
1School of Women and Children's Health, University of NSW, Randwick, NSW 2031, Australia. j.eden@unsw.edu.au
Objective:
To review the evidence that isoflavones are effective treatments for menopausal symptoms and to present the safety data.
Methods:
The databases Scopus, ScienceDirect and Primo Central Index were searched and preference was given to systematic reviews and meta-analyses.
Results:
The available evidence suggests that isoflavones do not relieve menopausal vasomotor symptoms any better than placebo. Long-term safety studies suggest that women who consume a diet high in isoflavones may have a lower risk of endometrial and ovarian cancer.
Conclusions:
Isoflavones cannot be recommended for the relief of hot flushes.
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