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Related Concept Videos

Ventilatory Modes01:14

Ventilatory Modes

Mechanical ventilators are life-saving devices that support or replace spontaneous breathing. They deliver breaths to patients through varying methods known as ventilator modes. Understanding these modes is critical for healthcare providers managing patients with respiratory failure.
There are three ventilatory modes: full support, partial support, and spontaneous. These are described below.
Full Support Modes
Full support modes include controlled mechanical ventilation, continuous mandatory...
Mechanical Ventilation II: Invasive Ventilation01:23

Mechanical Ventilation II: Invasive Ventilation

Ventilators are essential medical equipment used to aid patients with respiratory difficulties. Their primary function is to assist or replace spontaneous breathing by providing mechanical ventilation. There are two general classes of mechanical ventilators: negative-pressure and positive-pressure ventilators.
Negative-Pressure Ventilators
Negative-pressure ventilators create a vacuum around the chest or body to draw air into the lungs, simulating breathing. This method does not require an...
Mechanical Ventilation III: Noninvasive Ventilation01:23

Mechanical Ventilation III: Noninvasive Ventilation

Noninvasive positive-pressure ventilation (NIPPV), continuous positive airway pressure (CPAP), and bilevel positive airway pressure (BiPAP) are essential methods in respiratory care. These ventilation techniques offer unique benefits for patients with various respiratory conditions, providing adequate support without requiring intubation. Let's explore how each method is crucial in improving patient outcomes and enhancing respiratory therapy.
Noninvasive Positive-Pressure Ventilation (NIPPV)
Mechanical Ventilation I: Indication and Settings01:29

Mechanical Ventilation I: Indication and Settings

Mechanical ventilation is a life-saving technique for managing acute respiratory failure and other respiratory complications. The process involves using a machine known as a ventilator to supply oxygen to the lungs and assist in removing carbon dioxide. It serves as a bridge to long-term mechanical ventilation or a temporary measure until ventilatory support is discontinued. The ventilator can maintain this function for a prolonged period, providing critical support for patients until they can...
Assessment of Ventilation II: Respiratory Depth and Rhythm01:29

Assessment of Ventilation II: Respiratory Depth and Rhythm

Respiratory Depth
Respiratory depth measures the volume of air inhaled or exhaled during a breath. It can vary from shallow to deep and typically remains consistent when a person is at rest or asleep. Occasionally, individuals will automatically inhale deeply, known as sighing, which inflates the lungs with more air than normal breathing.
To assess respiratory depth, observe the degree of chest excursion or movement:
Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...

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Related Experiment Video

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Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide
04:16

Inspiratory Muscle Training as an Adjunct to the Treatment of Weaning Failure in Critically Ill Patients: A Practical Guide

Published on: January 30, 2026

Randomised weaning trial comparing assist control to pressure support ventilation.

Deena Shefali-Patel1, Vadivelam Murthy, Simon Hannam

  • 1Division of Asthma, Allergy and Lung Biology, Kings College London, London, UK.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|April 21, 2012
PubMed
Summary

Weaning infants using assist control ventilation (ACV) or pressure support ventilation (PSV) showed no significant differences in work of breathing, muscle strength, or asynchrony. Similar inflation times resulted in comparable weaning durations between the two ventilation methods.

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Area of Science:

  • Neonatal critical care
  • Respiratory physiology
  • Mechanical ventilation

Background:

  • Mechanical ventilation is crucial for neonates, but weaning strategies impact outcomes.
  • Assist control ventilation (ACV) and pressure support ventilation (PSV) are common modes, each with theoretical advantages.
  • Understanding differences in work of breathing, muscle strength, and asynchrony during weaning is essential for optimizing patient recovery.

Purpose of the Study:

  • To compare the work of breathing, respiratory muscle strength, and thoracoabdominal asynchrony in infants weaned via ACV versus PSV.
  • To determine if these physiological differences influence the duration of the weaning process.

Main Methods:

  • A randomized trial was conducted in a tertiary neonatal unit involving 36 infants (median gestational age 29 weeks).
  • Infants were weaned using either ACV or PSV.
  • Work of breathing (PTPdi), thoracoabdominal asynchrony (TAA), and respiratory muscle strength (Pimax) were assessed at multiple time points, along with weaning duration.

Main Results:

  • No significant differences were observed in PTPdi, TAA, or Pimax between the ACV and PSV groups at any assessment point.
  • Inflation times were similar for both ventilation modes.
  • The median duration of weaning was not significantly different between the ACV (34 hours) and PSV (27 hours) groups.

Conclusions:

  • Weaning infants with ACV and PSV, when utilizing similar inflation times, results in comparable physiological parameters and weaning durations.
  • These findings suggest that the choice between ACV and PSV may not critically impact weaning outcomes under these conditions.