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Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia
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Toe amputation: a predictor of future limb loss?

Kathryn J Griffin1, Tawqeer S Rashid, Marc A Bailey

  • 1The Leeds Vascular Institute, The General Infirmary at Leeds, Great George Street, Leeds LS1 3EX, United Kingdom. kgriffin@doctors.org.uk

Journal of Diabetes and Its Complications
|April 21, 2012
PubMed
Summary

Digital toe amputation predicts future limb loss. Patients without diabetes are at higher risk, suggesting a need for intensive follow-up care for these individuals.

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Area of Science:

  • Vascular Surgery
  • Diabetic Foot Care
  • Limb Salvage

Background:

  • Digital toe amputation, though minor, is historically linked to eventual limb loss.
  • Limited contemporary data exists on long-term outcomes following toe amputation.
  • This study investigates risk factors for subsequent limb loss after toe amputation.

Purpose of the Study:

  • To analyze long-term outcomes of patients undergoing digital toe amputation.
  • To identify risk factors predicting progression to major limb loss.
  • To evaluate the impact of diabetes on limb loss after toe amputation.

Main Methods:

  • Retrospective review of 63 patients who underwent toe amputation.
  • Construction of a database including vascular risk factors and comorbidities.
  • Statistical analysis using Chi-squared testing and logistic regression.

Main Results:

  • 55.6% of patients required further surgical amputation (22 major, 23 minor).
  • Diabetes was present in 68.3% of patients; 49.2% had revascularization.
  • Patients without diabetes showed a significant correlation with future limb loss (p=0.038).

Conclusions:

  • Digital toe amputation is a significant predictor of subsequent limb loss.
  • Diabetic patients demonstrated a lower risk of further limb loss, possibly due to intensive foot care.
  • Findings support enhanced outpatient services for high-risk patients post-toe amputation.