Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
The Antiviral System of Bacteria and Archaea: CRISPR01:23

The Antiviral System of Bacteria and Archaea: CRISPR

CRISPR stands for Clustered Regularly Interspaced Short Palindromic Repeats is a adaptive immune system found in bacteria and archaea that protects against viral infections. This system enables prokaryotic cells to identify, remember, and neutralize foreign genetic elements, primarily bacteriophages, by storing fragments of the invader’s DNA as a genetic memory.The CRISPR immune response begins during an initial infection. Cas (CRISPR-associated) proteins play a central role in this defense.
Acute Inflammation I: Inflammatory Response01:26

Acute Inflammation I: Inflammatory Response

Acute inflammation is a rapid, short-lived physiological response to tissue injury or infection, designed to eliminate harmful agents and initiate repair. This tightly regulated process typically lasts from minutes to several days and is triggered by factors such as microbial invasion, physical trauma, or chemical injury.Recognition and Mediator ReleaseThe inflammatory response begins when resident immune cells—such as mast cells, macrophages, and dendritic cells—detect damage-associated...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

DHA-Rich Algae Feed Modulates Atlantic Salmon Health, Microbiota and Stress Response.

Aquaculture nutrition·2026
Same author

Replacing fish oil with Tetraselmis chui microalgae biomass does not compromise rainbow trout health: Biochemical, histologic, antioxidant and immune gene expression.

Scientific reports·2026
Same author

Cytogenetic spectrum and clinical presentation of Klinefelter syndrome: A comprehensive study from South India.

Medical journal, Armed Forces India·2026
Same author

From prebiotics to engineered microbes: microbe-inspired treatments for atopic dermatitis.

The British journal of dermatology·2025
Same author

Calcium regulation of muscle spindle mechanosensory afferent function.

Experimental physiology·2025
Same author

Investigating the Effect of Enzymatically-Derived Blackcurrant Extract on Skin Staphylococci Using an In Vitro Human <i>Stratum Corneum</i> Model.

Pharmaceutics·2025

Related Experiment Video

Updated: May 23, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

Pattern recognition receptors in infectious skin diseases.

Heleen D de Koning1, Anna Simon, Patrick L J M Zeeuwen

  • 1Department of Dermatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB, The Netherlands. h.dekoning@derma.umcn.nl

Microbes and Infection
|April 21, 2012
PubMed
Summary

Pattern recognition receptors (PRRs) are key to innate immunity against pathogens. This review explores PRRs recognizing skin pathogens, highlighting their dual role and therapeutic potential.

More Related Videos

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
12:43

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
06:44

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Published on: January 26, 2019

Related Experiment Videos

Last Updated: May 23, 2026

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1
07:42

Fluorescence Assays for the Study of Mycobacterium tuberculosis Interaction with the Immune Receptor SLAMF1

Published on: February 28, 2025

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE
12:43

Monitoring Activation of the Antiviral Pattern Recognition Receptors RIG-I And PKR By Limited Protease Digestion and Native PAGE

Published on: July 29, 2014

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection
06:44

Confocal Imaging of Double-Stranded RNA and Pattern Recognition Receptors in Negative-Sense RNA Virus Infection

Published on: January 26, 2019

Area of Science:

  • Immunology
  • Microbiology
  • Dermatology

Background:

  • Pattern recognition receptors (PRRs) are crucial components of the innate immune system.
  • These receptors identify a wide range of pathogens, initiating immune responses.
  • Dysregulated PRR activity can contribute to disease pathogenesis, even during infection.

Purpose of the Study:

  • To review current knowledge on PRRs involved in recognizing dermatotropic pathogens.
  • To discuss the dual role of PRRs in both defense and potential harm during skin infections.
  • To explore the therapeutic implications of targeting PRRs in dermatological conditions.

Main Methods:

  • Literature review of studies on PRRs and dermatotropic pathogens.
  • Analysis of research on the mechanisms of PRR activation and signaling in skin.
  • Synthesis of information on the clinical relevance and therapeutic targeting of PRRs.

Main Results:

  • Several PRRs have been identified that specifically recognize pathogens targeting the skin.
  • PRR activation is essential for controlling skin infections but can also exacerbate inflammation.
  • Understanding PRR function offers insights into novel therapeutic strategies for skin diseases.

Conclusions:

  • PRRs play a complex role in the immune response to dermatotropic pathogens.
  • Targeting PRRs presents a promising avenue for developing new treatments for skin infections and inflammatory skin diseases.
  • Further research is needed to fully elucidate PRR pathways and their therapeutic applications in dermatology.