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Intestinal permeability and nutritional status in developmental disorders
Nilian Carla Silva Souza1, Jacqueline Nakau Mendonca, Guilherme Vannucchi Portari
1Ribeirao Preto School of Medicine, São Paulo University, [corrected] Brazil.
Individuals with autism may have increased intestinal permeability, indicated by a higher lactulose-to-mannitol ratio (L/M). This suggests potential gut barrier dysfunction that warrants further investigation into dietary modifications for autism symptoms.
Area of Science:
- Gastroenterology
- Neurodevelopmental Disorders
- Nutritional Science
Background:
- Autism spectrum disorder (ASD) is a developmental disorder where diet may influence symptom severity.
- Altered intestinal permeability could permit absorption of gluten and casein peptides, potentially affecting brain function and behavior.
Purpose of the Study:
- To evaluate intestinal permeability and nutritional status in individuals with developmental disorders.
- To identify potential intestinal mucosal barrier changes or intercellular junction injuries.
- To assess if dietary modifications are warranted for these individuals.
Main Methods:
- Intestinal permeability assessed via lactulose-to-mannitol (L/M) ratio in urine after sugar ingestion.
- Nutritional status evaluated through height, weight, bioelectric impedance, and dietary intake analysis.
- Seven participants with developmental disorders (DG) and seven controls (CG) were studied.
Main Results:
- The developmental group (DG) showed a higher L/M ratio and lower mannitol excretion compared to the control group (CG).
- Participants with developmental disorders were more likely to be overweight and had diets high in lipids, proteins, calories, and carbohydrates.
- Dietary analysis indicated high intake of gluten and casein sources in the DG.
- Increased L/M ratio suggests potential intestinal mucosal atrophy or intercellular junction injury.
Conclusions:
- Findings suggest potential intestinal abnormalities in individuals with developmental disorders.
- Further research is needed to confirm gut abnormalities and the efficacy of gluten and casein restrictions for improving autism symptoms.
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