Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...
Accessory Structures of the Eye01:17

Accessory Structures of the Eye

Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Sustainability awareness among European dry eye disease specialists.

European journal of ophthalmology·2026
Same author

Neuroinflammation and mononuclear phagocytes in glaucoma: From ocular pathogenesis to central visual pathway involvement - A comprehensive review.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Long-Term Evolution of Treatment Outcomes with Once-Daily Ciclosporin A 0.1% Cationic Emulsion in Patients with Dry Eye Disease and Severe Keratitis.

Ophthalmology and therapy·2026
Same author

Twelve-month outcomes after open bleb revision for Preserflo<sup>®</sup> microshunt bleb failure in refractory glaucoma patients.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie·2026
Same author

Efficacy and Safety of the Preserflo<sup>®</sup> Microshunt as a Standalone Procedure Versus Its Combination with Phacoemulsification.

Journal of clinical medicine·2026
Same author

A Systematic and Narrative Review of Safety and Complications in Minimally Invasive Glaucoma Surgery (MIGS) Between 2014-2024 [Response to Letter].

Clinical ophthalmology (Auckland, N.Z.)·2026

Related Experiment Video

Updated: May 23, 2026

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Ocular surface and external filtration surgery: mutual relationships.

Christophe Baudouin1

  • 1Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, INSERM, U968, UPMC University Paris 06, Institut de la Vision, Paris, and University of Versailles, St Quentin en Yvelines, France.

Developments in Ophthalmology
|April 21, 2012
PubMed
Summary

Long-term topical glaucoma drug use can harm the ocular surface, leading to inflammation and potential surgical failure. Preservatives like benzalkonium chloride are key culprits, causing significant eye tissue damage.

More Related Videos

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Related Experiment Videos

Last Updated: May 23, 2026

Ultrasound Cyclo Plasty in Eyes with Glaucoma
05:05

Ultrasound Cyclo Plasty in Eyes with Glaucoma

Published on: January 26, 2018

Iris Fixation via External Pentagram Suturing
05:22

Iris Fixation via External Pentagram Suturing

Published on: May 5, 2022

Area of Science:

  • Ophthalmology
  • Ocular Surface Disease
  • Glaucoma Management

Background:

  • Long-term topical drug use, particularly for glaucoma, is linked to ocular surface changes.
  • These changes include dry eye, inflammation, fibrosis, and corneal impairment, increasing glaucoma surgery failure risk.
  • Subclinical inflammation and fibroblast activation are common in patients on long-term antiglaucoma treatments.

Purpose of the Study:

  • To investigate the impact of topical drugs and preservatives on ocular surface health.
  • To understand the role of ocular surface changes in glaucoma surgery outcomes.
  • To highlight the need for a new paradigm in glaucoma care focusing on ocular surface management.

Main Methods:

  • Review of clinical and experimental evidence on topical drug effects.
  • Analysis of preservative toxicity, specifically benzalkonium chloride.
  • Examination of the relationship between preoperative ocular surface status and postoperative surgical outcomes.

Main Results:

  • Topical drugs, especially those with benzalkonium chloride, induce significant ocular surface toxicity.
  • Adverse effects include tear film instability, cell damage, and chronic inflammation.
  • Preoperative ocular surface inflammation is a predictor of postoperative fibrosis and surgical failure.

Conclusions:

  • Ocular surface damage from topical glaucoma medications is a significant clinical issue.
  • Benzalkonium chloride is a major contributor to drug-induced ocular surface toxicity.
  • Comprehensive ocular surface evaluation and management are crucial for successful long-term glaucoma care and surgical outcomes.