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Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
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Related Experiment Video

Updated: May 23, 2026

Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome
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Ultrasound-Guided Needle Release Combined with Corticosteroid Injection for the Treatment of Supinator Syndrome

Published on: May 26, 2023

Corticosteroid-sparing agents: new treatment options.

Oren Tomkins-Netzer1, Simon R J Taylor, Sue Lightman

  • 1Royal Surrey County Hospital, Guildford, UK.

Developments in Ophthalmology
|April 21, 2012
PubMed
Summary

Corticosteroids are key for noninfectious uveitis but have side effects. Steroid-sparing agents and local treatments offer alternatives, balancing efficacy with improved safety profiles for ocular inflammation management.

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Area of Science:

  • Ophthalmology
  • Immunology

Background:

  • Corticosteroids are primary treatments for noninfectious uveitis.
  • Their adverse effects necessitate alternative therapeutic strategies.

Purpose of the Study:

  • To review steroid-sparing agents and local drug administration for noninfectious uveitis.
  • To discuss the risks and benefits of these alternative approaches.

Main Methods:

  • Review of systemic immunomodulatory drugs adopted from other specialties.
  • Analysis of local drug administration techniques for ocular inflammation.

Main Results:

  • Systemic agents, while alternatives to corticosteroids, can cause problematic side effects.
  • Local administration avoids systemic issues but may lead to ocular complications.

Conclusions:

  • Both steroid-sparing agents and local treatments aim to mitigate corticosteroid risks.
  • Careful consideration of risks and benefits is crucial for managing noninfectious uveitis.