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Updated: May 23, 2026
Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
Published on: August 7, 2017
Nasopharyngeal lactate dehydrogenase concentrations predict bronchiolitis severity in a prospective multicenter
Jonathan M Mansbach1, Pedro A Piedra, Federico R Laham
1Department of Medicine, Children's Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. jonathan.mansbach@childrens.harvard.edu
Abstract:
We reexamined the finding of an inverse relationship between values of nasopharyngeal lactate dehydrogenase, a marker of the innate immune response, and bronchiolitis severity. In a prospective, multicenter study of 258 children, we found in a multivariable model that higher nasopharyngeal lactate dehydrogenase values in young children with bronchiolitis were independently associated with a decreased risk of hospitalization.