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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
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Viral epidemiology and severity of respiratory infections in infants in 2009: a prospective study

Carmen Laurent1, Audrey E Dugué, Jacques Brouard

  • 1CHU de Caen, Department of Pediatrics, Caen, France.

The Pediatric Infectious Disease Journal
|April 21, 2012
PubMed

Insights

The 2009 pandemic influenza H1N1 virus (H1N1v2009) caused fewer severe respiratory infections in infants than other viruses. Respiratory syncytial virus (RSV) posed a higher risk for severe illness and intensive care unit admissions.

Area of Science:

  • Pediatric infectious diseases
  • Virology
  • Epidemiology

Background:

  • Infants are susceptible to severe viral respiratory infections.
  • The H1N1v2009 influenza strain raised concerns for severe infant outcomes.

Purpose of the Study:

  • To assess the H1N1v2009 impact on infant respiratory infection epidemiology.
  • To evaluate clinical presentation and severity of H1N1v2009 in infants.

Main Methods:

  • Prospective study of infants (<2 years) with respiratory symptoms (Nov 2009-Apr 2010).
  • Nasal swabs analyzed via immunofluorescence and PCR for viral detection.
  • Severe respiratory infection defined by a standardized severity score.

Main Results:

  • Respiratory syncytial virus (34.2%), rhinoviruses (23.9%), coronaviruses (9.3%), and H1N1v2009 (7.7%) were most common.
  • H1N1v2009 infections showed lower risk of severity (OR=0.15) and hospitalization (OR=0.40) compared to other viruses.
  • Respiratory syncytial virus infections carried a high risk of severity (OR=7.85) and ICU admission (71.4%).

Conclusions:

  • H1N1v2009 had a modest impact on infant respiratory infections in this cohort.
  • Continued surveillance is necessary to identify factors influencing H1N1v2009 severity.
Abstract

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