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Synthetic retinoids in veterinary dermatology
1Department of Medicine, University of California School of Veterinary Medicine, Davis.
The Veterinary Clinics of North America. Small Animal Practice
|November 1, 1990
Summary
Synthetic retinoids, isotretinoin (Accutane) and etretinate (Tegison), are vitamin A analogs impacting epithelial differentiation. They show therapeutic potential for keratinization defects and cutaneous neoplasia, with pharmacology, uses, and toxicities discussed.
Area of Science:
- Dermatology
- Pharmacology
- Oncology
Background:
- Synthetic retinoids are vitamin A analogs.
- These compounds influence epithelial cell differentiation.
- Disorders of epithelial maturation, including keratinization defects and cutaneous neoplasia, are common.
Purpose of the Study:
- To discuss the pharmacology of synthetic retinoids.
- To review indications and clinical experience with isotretinoin and etretinate.
- To outline potential toxicities and monitoring guidelines for these drugs.
Main Methods:
- Literature review of pharmacology.
- Analysis of clinical trial data.
- Synthesis of safety and monitoring information.
Main Results:
- Isotretinoin and etretinate demonstrate effects on epithelial differentiation.
- These drugs have established therapeutic roles in specific dermatological conditions.
- Potential toxicities necessitate careful patient monitoring.
Conclusions:
- Synthetic retinoids are valuable therapeutic agents for epithelial disorders.
- Understanding their pharmacology and toxicity is crucial for safe and effective use.
- Further research may expand their applications in cutaneous neoplasia.