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Cyclic 3',5'-adenosine monophosphate (cAMP) in a 42-month-old child with clinical evidence of multiple hormonal

B Hager-Małecka, F Sliwa, W Janiec

    European Journal of Pediatrics
    |August 1, 1979
    PubMed

    Insights

    This study identified a rare hormonal disorder in a child with growth and developmental issues. The findings suggest a faulty adenyl cyclase system causing tissue insensitivity to multiple hormones.

    Area of Science:

    • Endocrinology
    • Pediatrics
    • Molecular Biology

    Background:

    • Multihormonal disturbances can present with complex symptoms in children.
    • Assessing hormonal function requires evaluating both hormone levels and cellular response.

    Observation:

    • A 42-month-old boy exhibited small stature, psychomotor delay, dry skin, polydipsia, polyuria, cryptorchidism, and rickets.
    • Despite clinical signs of hormonal imbalance, plasma levels of growth hormone (hGH), insulin, thyroid hormones (T3RU, T4), thyroid-stimulating hormone (TSH), and parathyroid hormone (PTH) were normal or elevated.

    Findings:

    • Plasma cyclic adenosine monophosphate (cAMP) levels were low, with reduced urinary cAMP excretion.
    • Administration of various hormones (hGH, adrenaline, T3, T4, pitressin, vitamin D3) and aminophylline did not increase cAMP levels in plasma or urine.

    Implications:

    • The results suggest a deficient adenyl cyclase system as the underlying cause.
    • This deficiency may lead to a clinical syndrome of tissue insensitivity to multiple hormones.
    • Further research into adenyl cyclase dysfunction is warranted for understanding rare pediatric endocrine disorders.

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