Estimation of the timing of carotid artery flow using peripheral pulse wave-gated MRI

To investigate the relationship between peripheral pulse wave (PPW)-gating and the carotid systolic pulse wave in a large clinical patient cohort, and to establish a process for correct estimation of delay time from PPW-gating to foot (ie, beginning) or peak times of carotid systolic pulse waves.

Subjects comprised 209 patients scanned using 3T magnetic resonance imaging (MRI) for PPW-gated phase contrast images at the common carotid artery. Stepwise multiple regression analysis was conducted for the relationship between foot or peak times and the following factors after excluding correlated factors with coefficients ≥0.5: pulse rate (PR); systolic blood pressure; diastolic blood pressure; height; body weight; body mass index; Brinkman index; diabetes mellitus; hypertension; and hyperlipidemia.

PR showed significant correlation with foot (r = -0.86, P < 0.001) and peak (r = -0.87, P < 0.001) times. The following equations were derived: foot time (msec) = -8.55 × PR + 993.1 and peak time (msec) = -9.21 × PR + 1142.3. No other factors showed significant correlations.

PR was the only factor showing significant relationships to foot and peak times of carotid artery flow. The derived equations will facilitate various kinds of noncontrast MR acquisition with simple PPW-gating.