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Updated: May 23, 2026
A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Long-term serial angiographic outcomes after sirolimus-eluting stent implantation
Euihong Ko1, Kenya Nasu, Maoto Habara
1Department of Cardiology, Toyohashi Heart Center, Toyohashi, Japan.
Insights
Sirolimus-eluting stents (SES) showed continuous neointima progression, indicating a potential late catch-up phenomenon. Increased late loss after SES implantation may signify this risk.
Area of Science:
- Cardiovascular Medicine
- Interventional Cardiology
- Biomedical Engineering
Background:
- Drug-eluting stents (DES) have reduced revascularization rates but raise concerns about the
- late catch-up
- phenomenon.
Purpose of the Study:
- To evaluate the natural history of target lesions after sirolimus-eluting stent (SES) implantation using quantitative coronary angiography.
- To identify predictors of the
- late catch-up
- phenomenon.
Main Methods:
- Quantitative coronary angiography was used to assess changes in target lesions.
- 217 patients with 306 lesions underwent early (11.2 months) and late (29.4 months) angiographic follow-up.
- Univariate and multivariate regression analyses identified predictors of late catch-up.
Main Results:
- Reference vessel diameter remained stable, but late loss (LL) significantly increased over time (P < 0.0001).
- %
- Diameter stenosis (%DS) at early follow-up was a significant predictor of late catch-up (OR 1.076, P < 0.0001).
Conclusions:
- Sirolimus-eluting stent (SES) implantation is associated with significant and continuous neointima progression.
- Increased late loss (LL) may indicate the
- late catch-up
- phenomenon after SES implantation.
Objective:
We evaluated, using quantitative coronary angiography, the natural history of change that occurred in target lesions after successful sirolimus-eluting stent (SES) implantation.
Background:
Percutaneous coronary intervention with drug-eluting stents (DES) has significantly reduced the rate of repeated target lesion revascularization. However, early studies have raised concerns regarding the "late catch-up" phenomenon of DES.
Methods:
Between June 2004 and March 2007, consecutive 217 patients with 306 lesions without restenosis at early angiographic follow-up underwent late angiographic follow-up (early follow-up: 11.2 ± 2.1 months and late follow-up: 29.4 ± 5.2 months). Predictors of late catch-up were identified with univariate and multivariate regression analyses.
Results:
Although reference vessel diameter did not significantly change during follow-up [3.15 mm (interquartile range (IQR): 2.81-3.49 mm), 3.12 mm (IQR: 2.79-3.47 mm), and 3.08 mm (IQR: 2.76-3.46 mm) at postprocedure, and early and late angiographic follow-up, respectively; P = 0.2653], late loss (LL) significantly increased during follow-up [0.05 mm (IQR: 0.00-0.13 mm) and 0.08 mm (IQR: 0.01-0.19 mm) at early and late follow-up, respectively; P < 0.0001]. Univariate analysis showed previous intervention, adjunctive use of cutting balloon, lesion length, and progression of MLD, LL, %DS at early follow-up as predictors of late catch-up. Multivariate regression analysis identified %DS at early follow-up as a predictor of late catch-up (OR 1.076, CI 1.039-1.114, P < 0.0001).
Conclusion:
Significant and continuous progression of neointima after SES implantation was observed in the present study. Larger LL may be a sign of late catch-up phenomenon.