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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Drugs that Stabilize Microtubules01:15

Drugs that Stabilize Microtubules

Microtubules are dynamic structures that undergo cycles of catastrophe and rescue. The microtubules play a central role in cell division by forming the spindle apparatus for segregating the chromosomes. This makes them ideal targets for regulating dividing cells in tumors and malignant cancer cells. Microtubule stabilizing drugs help stabilize the microtubule formation and promote its polymerization. Paclitaxel was the first microtubule stabilizing agent used as anticancer drug in chemotherapy...
Cancer Therapies02:49

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
Drugs that Destabilize Microtubules01:10

Drugs that Destabilize Microtubules

Microtubules are dynamic structures and can be regulated by microtubule targeting agents (MTAs). Microtubule destabilizing drugs are a class of MTAs that destabilize and prevent microtubules' polymerization. Both natural and synthetic chemicals can be found under this class of drugs. Vincristine and vinblastine, two vinca alkaloids, and colchicine were among the first to be discovered. These drugs can affect cells in various ways, either by inducing a change in cell morphology, preventing...

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Related Experiment Video

Updated: May 23, 2026

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
08:03

Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

Published on: December 1, 2016

Docetaxel nanotechnology in anticancer therapy.

Pengxiang Zhao1, Didier Astruc

  • 1ISM, UMR CNRS No. 5255, Univ. Bordeaux, 33405 Talence Cedex, France.

Chemmedchem
|April 21, 2012
PubMed
Summary

New nanotechnology-based drug delivery systems offer improved docetaxel formulations. These systems utilize nanocarriers and targeting agents to overcome Taxotere

Area of Science:

  • Oncology
  • Nanotechnology
  • Drug Delivery

Background:

  • Taxanes, including paclitaxel and docetaxel, are effective anticancer agents but have significant side effects.
  • Current docetaxel formulations (e.g., Taxotere) suffer from toxicity and poor solubility.
  • Limited new clinical formulations for docetaxel exist, highlighting the need for advanced delivery systems.

Purpose of the Study:

  • To review academic approaches in nanotechnology-based drug delivery for docetaxel.
  • To explore the potential of nanocarriers and targeting agents for improved docetaxel formulations.
  • To discuss the development of novel docetaxel treatments overcoming current limitations.

Main Methods:

  • Review of published academic research on nanotechnology-based docetaxel formulations.

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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles
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Anticancer Efficacy of Photodynamic Therapy with Lung Cancer-Targeted Nanoparticles

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Encapsulation of Cancer Therapeutic Agent Dacarbazine Using Nanostructured Lipid Carrier
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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice
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Sample Extraction and Simultaneous Chromatographic Quantitation of Doxorubicin and Mitomycin C Following Drug Combination Delivery in Nanoparticles to Tumor-bearing Mice

Published on: October 5, 2017

  • Analysis of engineered nanosystems combining nanocarriers, targeting agents, and docetaxel.
  • Evaluation of in vitro, in vivo, and pre-clinical data for novel docetaxel delivery systems.

    • Main Results:

    • Numerous academic approaches have developed docetaxel delivery systems using nanocarriers and targeting agents.
    • Engineered nanosystems demonstrate more efficient docetaxel transport and vectorization compared to Taxotere.
    • Emerging theranostic approaches integrate therapy and diagnostics within a single delivery vector.

    Conclusions:

    • Nanotechnology-based systems show significant promise for overcoming docetaxel's limitations.
    • These advanced formulations are expected to enhance docetaxel's efficacy in cancer treatment.
    • Future docetaxel therapies may benefit from these innovative drug vectorization strategies.