Related Experiment Video
Updated: May 23, 2026
06:48
Fingerprinting Cardiolipin in Leukocytes by Mass Spectrometry for a Rapid Diagnosis of Barth Syndrome
Published on: March 23, 2022
Antenatal bartter syndrome: a review
Y Ramesh Bhat1, G Vinayaka, K Sreelakshmi
1Department of Paediatrics, Kasturba Medical College, Manipal University, Udupi District, Manipal 576104, India.
International Journal of Pediatrics
|April 21, 2012
Summary
Antenatal Bartter syndrome (ABS) is a rare kidney disorder causing fetal polyuria and maternal polyhydramnios. Early diagnosis and indomethacin treatment improve pregnancy outcomes and infant health.
Area of Science:
- Nephrology
- Obstetrics
- Genetics
Background:
- Antenatal Bartter syndrome (ABS) is a rare autosomal recessive renal tubular disorder.
- Defective chloride transport in the loop of Henle causes fetal polyuria, leading to severe hydramnios and premature delivery.
Purpose of the Study:
- To present a comprehensive overview of Antenatal Bartter syndrome (ABS).
- To discuss classification, pathophysiology, clinical manifestations, laboratory findings, complications, and prognosis of ABS.
Main Methods:
- Review of existing literature on Antenatal Bartter syndrome.
- Analysis of clinical features, biochemical findings, and treatment outcomes.
Main Results:
- Early onset, unexplained maternal polyhydramnios should raise suspicion for ABS.
- Elevated amniotic fluid chloride levels are diagnostic.
- Neonatal complications include polyuria, failure to thrive, and nephrocalcinosis.
Conclusions:
- Awareness and early recognition of ABS are crucial.
- Maternal treatment with indomethacin and amniocentesis can prolong pregnancy.
- Prenatal diagnosis and timely intervention improve infant prognosis.
Related Concept Videos
01:21Barrett Esophagus-I: Introduction
Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more similar...
01:21Barrett Esophagus-II: Clinical Manifestations and Management
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure entails...
01:24Renal Tubule and Collecting Duct
The renal tubule is divided into three parts: the proximal convoluted tubule (PCT), the Loop of Henle (LOH), and the distal convoluted tubule (DCT).
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
01:33Hormonal Regulation
The renin-aldosterone system is an endocrine system which guides the renal absorption of water and electrolytes, thus managing blood pressure and osmoregulation. Activation of the system begins in the kidneys with a small cluster of cells adjacent to the afferent and efferent blood vessels of the renal corpuscle. As the nephrons are filtering blood, juxtaglomerular cells monitor blood pressure. If they detect a decrease in pressure, they release the hormone renin into the bloodstream.
01:29Acute Kidney Injury II: Pathophysiology
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
01:28Kidney Transplant I: Introduction
A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...