Flow injection/sequential injection analysis systems: potential use as tools for rapid liver diseases biomarker study

Area of Science:

• Analytical Chemistry
• Biochemical Analysis
• Clinical Diagnostics

Background:

• Flow injection analysis (FIA) and sequential injection analysis (SIA) systems enable automated wet chemical and biochemical reactions.
• These systems offer reduced reagent consumption and analysis times compared to traditional methods.
• Components like pumps, valves, and reactors can be adapted from readily available materials, leading to lower instrumentation costs.

Purpose of the Study:

• To summarize the applications of FIA/SIA systems in determining biomarkers for liver diseases.
• To provide a guide for utilizing flow-based systems in expanded biomarker and multibiomarker studies.
• To highlight the versatility of FIA/SIA for various reaction types in diagnostic contexts.

Main Methods:

• Review of existing literature on FIA/SIA applications for biomarker determination.
• Categorization of applications based on reaction types and targeted biomarkers.
• Analysis of system components and cost-effectiveness.

Main Results:

• FIA/SIA systems have been successfully applied to determine various liver disease biomarkers.
• Demonstrated effectiveness in different operational formats, showcasing system adaptability.
• The potential for low-cost, automated analysis using adaptable components is evident.

Conclusions:

• FIA/SIA systems are valuable tools for automated biomarker analysis, especially in liver disease diagnostics.
• The reviewed applications demonstrate the potential for broader implementation in multibiomarker studies.
• Further development and application of FIA/SIA can enhance cost-effective and efficient diagnostic strategies.