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Updated: May 23, 2026

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The Use of Reverse Phase Protein Arrays (RPPA) to Explore Protein Expression Variation within Individual Renal Cell Cancers
Published on: January 22, 2013
[Pax-2 antigen expression in kidney tumours]
Jelena M Vjestica1, Jasmina Marković-Lipkovski, Cane D Tulić
1Institut za patologiju, Beograd.
Acta Chirurgica Iugoslavica
|April 24, 2012
Summary
Pax-2 is a useful marker for kidney tumors, showing stronger expression in less malignant types like oncocytomas. This finding aids in diagnosing renal cell carcinoma (RCC) and differentiating tumor grades.
Area of Science:
- Oncology
- Molecular Biology
- Nephrology
Context:
- Pax-2 transcription factor plays a role in kidney development.
- Pax-2 can be re-expressed in renal tumors.
- Understanding Pax-2 expression in renal cell carcinoma (RCC) is crucial for diagnostics.
Purpose:
- To investigate Pax-2 expression in various types of renal cell carcinoma (RCC).
- To evaluate Pax-2 as a potential immunohistochemical marker for renal tumors.
Summary:
- Pax-2 expression was analyzed in 48 renal tumors using immunohistochemistry.
- Pax-2 was detected in a high percentage of renal tumors across different histological types.
- A significant difference in Pax-2 expression was observed between oncocytomas and chromophobe RCC.
Impact:
- Nuclear Pax-2 expression serves as a valuable diagnostic marker for kidney tumors.
- Pax-2 demonstrates stronger expression in lower-grade renal tumors and oncocytomas compared to high-grade RCC, including those with sarcomatoid differentiation.

