Related Experiment Video

Updated: May 23, 2026

Kidney Procurement in a Preclinical Large Animal Model
05:36

Kidney Procurement in a Preclinical Large Animal Model

Published on: May 2, 2025

[Preemptive kidney transplantation in children--experience in UHC Zagreb]

Josip Pasini1, Vilka Bekavac Misak, Tomislav Kulis

  • 1Klinika za urologiju, Medicinski fakultet Sveucilista u Zagrebu, KBC Zagreb.

Lijecnicki Vjesnik
|April 24, 2012
PubMed

Insights

Preemptive kidney transplantation in children with end-stage kidney disease shows excellent graft survival rates. This approach offers optimal medical and socioeconomic benefits for pediatric patients.

Area of Science:

  • Pediatric Nephrology
  • Transplantation Surgery
  • Immunology

Context:

  • End-stage kidney disease (ESKD) in children necessitates renal replacement therapy.
  • Dialysis presents significant challenges for pediatric patients and their families.
  • Preemptive kidney transplantation avoids the complications associated with pre-transplant dialysis.

Purpose:

  • To evaluate the outcomes of preemptive kidney transplantation in children.
  • To assess graft and patient survival rates in this cohort.
  • To highlight the advantages of preemptive transplantation for pediatric ESKD.

Summary:

  • Six pediatric patients (<18 years) underwent preemptive living donor kidney transplantation.
  • Pre-transplant creatinine clearance averaged 9 mL/min.
  • One, three, and five-year graft survival was 100%, with overall graft and patient survival at 83.3% and 100%, respectively.
  • One patient required dialysis after 10 years due to chronic rejection.

Impact:

  • Preemptive kidney transplantation is an optimal treatment for pediatric ESKD.
  • This strategy improves both medical and socioeconomic outcomes.
  • Increased access to preemptive transplantation, potentially through programs like Eurotransplant, could benefit more children.
Abstract

More Related Videos

Murine Kidney Transplant Technique08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

Related Concept Videos

Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living donor...
Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in critically...