Related Experiment Video

Updated: May 23, 2026

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix
10:21

Scanning Electron Microscopy of Macerated Tissue to Visualize the Extracellular Matrix

Published on: June 14, 2016

Myocardial structure and matrix metalloproteinases

C Aggeli1, P Pietri, I Felekos

  • 11st Cardiology Department, Hippokrateion Hospital, Athens Medical School, Athens, Greece. caggeli@otenet.gr

Current Topics in Medicinal Chemistry
|April 24, 2012
PubMed

Insights

Matrix metalloproteinases (MMPs) are enzymes involved in tissue breakdown. This review details their structure, function, and crucial role in cardiovascular diseases and myocardial remodeling.

Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Enzymology

Background:

  • Matrix metalloproteinases (MMPs) are key enzymes responsible for extracellular matrix proteolysis.
  • Their significant pathophysiologic and prognostic roles are well-established in various disease contexts.
  • Understanding MMPs is crucial for comprehending tissue remodeling processes.

Purpose of the Study:

  • To provide a comprehensive overview of matrix metalloproteinases (MMPs).
  • To explore the structural and functional characteristics of MMPs.
  • To elucidate the role of MMPs in myocardial remodeling within cardiovascular diseases.

Main Methods:

  • Literature review of studies on MMPs.
  • Analysis of MMPs' structural and functional properties.
  • Examination of MMPs' involvement in cardiovascular pathophysiology.

Main Results:

  • MMPs exhibit diverse structural and functional properties.
  • MMPs play a significant role in the complex process of myocardial remodeling.
  • Their activity is implicated in several cardiovascular diseases.

Conclusions:

  • Matrix metalloproteinases are critical regulators of extracellular matrix turnover.
  • MMPs are integral to the mechanisms underlying myocardial remodeling in cardiovascular disease.
  • Assessment of MMPs holds potential clinical and therapeutic implications.

More Related Videos

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography07:32

Bacterial Expression and Purification of Human Matrix Metalloproteinase-3 using Affinity Chromatography

Published on: March 30, 2022

Detection of Functional Matrix Metalloproteinases by Zymography09:30

Detection of Functional Matrix Metalloproteinases by Zymography

Published on: November 8, 2010

Related Concept Videos

Role of Matrix Metalloproteases in Degradation of ECM01:23

Role of Matrix Metalloproteases in Degradation of ECM

Matrix metalloproteases (MMPs) are enzymes involved in the hydrolysis of proteins and glycoproteins of the extracellular matrix. MMPs are essential for the migration and proliferation of cells through the dense matrix network, throughout embryonic development, and throughout morphogenesis. The first MMP activity discovered was a collagenase in a tadpole's tail undergoing metamorphosis. The active collagen deposition and modifications lead to the morphogenesis of tadpoles into the adult body.
A...
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
Structure of Cardiac Muscles01:13

Structure of Cardiac Muscles

Cardiac muscle, or myocardium, is a specialized type of muscle found exclusively in the heart. Its unique structural and functional characteristics enable the heart to perform its vital role of pumping blood throughout the body continuously and rhythmically. The cardiac muscle cells, or cardiomyocytes, possess an endomysium and perimysium but do not have an epimysium.
Compared to skeletal muscles, cardiac muscle cells are small and mostly have a single nucleus. Additionally, they are usually...
The Extracellular Matrix01:42

The Extracellular Matrix

Overview
The Extracellular Matrix01:29

The Extracellular Matrix

Overview
In order to maintain tissue organization, many animal cells are surrounded by structural molecules that make up the extracellular matrix (ECM). Together, the molecules in the ECM maintain the structural integrity of tissue as well as the remarkable specific properties of certain tissues.
Composition of the Extracellular Matrix
The extracellular matrix (ECM) is commonly composed of ground substance, a gel-like fluid, fibrous components, and many structurally and functionally diverse...
Cell-matrix's Response to Mechanical Forces01:13

Cell-matrix's Response to Mechanical Forces

In animal cells, the extracellular matrix allows cells within tissues to withstand external stresses and transmits signals from the outside of the cell to the inside. The extracellular matrix is extensive, and its composition varies between different types of tissues. For example, the reticular fibers and ground substance make up the ECM in loose connective tissue, while collagen and bone minerals make up the ECM of bone tissue. 
Anchoring junctions mechanically attach a cell to the...