[Effect of preparations that alter the cyclic nucleotide level on acetylation processes]

The action of stimulants and imitators of the adenylate cyclase function (novodrin, sodium fluoride, cAMP), imitators of the guanylcyclase function (cGMP), inhibitors of adenylate cyclase (propranolol), izanylate cyclase (atropin) or phosphodiesterase (euphyllin, papaverin) on the body acetylating capacity measured from acetyl-PABA release, and CoA content in the liver was studied in experiments on male rats. The substances that mainly produce an increase in cAMP in the tissues augment the CoA endogenic pool and, as a rule, stimulate the acetylating capacity of the body. As compared to cAMP, the eczogenic cGMP raises, but to a significantly less measure, the CoA content and does not change the rate of arylamine acetylation. Paraverin is an exception to the rule since it seems to exert a direct action on the enzymatic system of acetylation. When administered to rats cGMP elicits a cAMP-like but a weaker action on the CoA pool. It is suggested that combined use of test substances prolonging cAMP effects and drugs belonging to a group of arylamines is not advisable because of active inactivation of the latter compounds.