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Severity of rotavirus gastroenteritis in Indian children requiring hospitalization

Thuppal V Sowmyanarayanan1, Sasirekha Ramani, Rajiv Sarkar

  • 1Department of Gastrointestinal Sciences, Christian Medical College, Vellore, India.

Vaccine
|April 24, 2012
PubMed

Insights

Two rotavirus gastroenteritis scoring systems, Clark

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Public Health

Background:

  • Rotavirus gastroenteritis poses a significant health burden, particularly in developing nations.
  • The development of rotavirus vaccines necessitates standardized methods for assessing disease severity.
  • Existing severity scoring systems may not consistently categorize disease intensity.

Purpose of the Study:

  • To compare the Vesikari and Clark scoring systems for rotavirus gastroenteritis severity assessment.
  • To evaluate the suitability of current scoring systems for vaccine efficacy trials and surveillance.

Main Methods:

  • Enzyme immunoassay and hemi nested multiplex RT-PCR were used to detect rotavirus in stool samples from 1001 children.
  • Clinical data for gastroenteritis assessment was collected from 934 children.
  • The Vesikari and Clark scoring systems were applied to assess disease severity.

Main Results:

  • Rotavirus was detected in 35.4% of hospitalized children.
  • The Vesikari and Clark scores showed moderate correlation but significant differences in classifying severe disease.
  • Vesikari scoring categorized 66.1% as severe, while Clark scoring identified only 1.6% as severe.

Conclusions:

  • Significant discrepancies exist between the Vesikari and Clark scoring systems in defining severe rotavirus gastroenteritis.
  • A standardized and robust scoring system is crucial for accurate rotavirus vaccine efficacy evaluation and post-licensure surveillance.
  • Further research is needed to establish a universally accepted severity assessment tool.
Abstract

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