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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients

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Clinical profile of Malay children with optic neuritis

Ismail Shatriah1, Abdul-Rahim Adlina, Salem Alshaarawi

  • 1Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Kelantan, Malaysia. shatriah@kck.usm.my

Pediatric Neurology
|April 24, 2012
PubMed

Insights

Optic neuritis in Malaysian children often presents bilaterally, with infections being a common cause. Progression to multiple sclerosis is less frequent than in other Asian populations.

Area of Science:

  • Ophthalmology
  • Pediatrics
  • Neurology

Background:

  • Optic neuritis (ON) is an inflammatory condition affecting the optic nerve, with limited data on its presentation in Asian children.
  • Clinical characteristics of ON can vary significantly across different racial and ethnic groups.
  • Understanding these variations is crucial for accurate diagnosis and management in diverse pediatric populations.

Purpose of the Study:

  • To investigate the clinical manifestations, visual outcomes, and etiologies of optic neuritis in Malaysian children.
  • To compare these findings with existing literature on optic neuritis in other Asian pediatric populations.
  • To provide insights into the specific characteristics of ON in this demographic.

Main Methods:

  • A retrospective study was conducted at Hospital Universiti Sains Malaysia involving 14 pediatric patients diagnosed with optic neuritis.
  • Data collected included clinical features, laboratory results, identified etiologies, and visual acuity at presentation and 1-year follow-up.
  • Visual field defects and progression to demyelinating diseases were also analyzed.

Main Results:

  • The study included 14 children (predominantly female) with a mean age of 11.1 years at presentation, all exhibiting bilateral optic nerve involvement.
  • At presentation, 60.7% had visual acuity of 6/60 or worse; 14.3% had persistent visual impairment at 1 year.
  • Infections accounted for 50% of cases, and 14.3% progressed to multiple sclerosis during the follow-up period.

Conclusions:

  • The clinical profile and etiologies of optic neuritis in Malaysian children show some differences compared to other Asian cohorts.
  • Infection is a significant cause, and the rate of progression to multiple sclerosis appears relatively lower in this population.
  • Further research is warranted to elucidate the specific factors influencing optic neuritis in Malaysian children.

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