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Related Experiment Video

Updated: May 23, 2026

Epithelial Cell Infection Analyses with Shigella

Epithelial Cell Infection Analyses with Shigella

Published on: February 9, 2024

Shigella navigates tight corners.

Manuel Amieva¹

¹Departments of Pediatrics and Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA. amieva@stanford.edu

Cell Host & Microbe

|April 24, 2012

Summary

This summary is machine-generated.

Shigella bacteria spread between cells at specific tricellular junctions. The protein tricellulin is crucial for this Shigella cell-to-cell invasion process.

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Area of Science:

Microbiology
Cell Biology
Infectious Diseases

Background:

Shigella is a pathogen that causes bacillary dysentery.
Understanding Shigella's cell-to-cell spread is key to controlling infection.

Discussion:

Shigella utilizes unique tricellular junctions for intercellular spread.
These junctions are formed where three cells meet.
The tight junction protein tricellulin is localized at these sites.

Key Insights:

Shigella protrusions actively invade adjacent cells at tricellular junctions.
Tricellulin plays a significant role in mediating Shigella's cell-to-cell transmission.
This identifies a novel mechanism for bacterial dissemination.

Outlook:

Targeting tricellular junctions or tricellulin could be a strategy to inhibit Shigella spread.
Further research into host-pathogen interactions at tricellular junctions is warranted.
This finding opens new avenues for therapeutic interventions against Shigella infections.