[Estimating glomerular filtration rate in 2012: which adding value for the CKD-EPI equation?]

Area of Science:

• Nephrology
• Renal Function Assessment

Context:

• Glomerular filtration rate (GFR) estimation is crucial for assessing global renal function.
• The Modification of Diet in Renal Disease (MDRD) study equation was previously a standard for GFR estimation.
• The 2009 CKD-EPI equation emerged as a potentially superior alternative.

Purpose:

• To review and critically evaluate the performance of the 2009 CKD-EPI equation for GFR estimation.
• To compare the CKD-EPI equation with the MDRD study equation.
• To identify the advantages and limitations of the CKD-EPI equation based on recent literature.

Summary:

• The CKD-EPI equation demonstrates improved GFR estimation compared to MDRD, particularly at higher GFR levels.
• Key advantages include a more accurate understanding of chronic kidney disease prevalence.
• Limitations exist, especially concerning performance in specific patient populations.

Impact:

• The CKD-EPI equation enhances the accuracy of chronic kidney disease prevalence data.
• Findings underscore the need for careful interpretation of estimated GFR, as equations are approximations.
• Highlights the importance of considering population-specific performance for accurate clinical application.