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Risperidone-induced leukopenia: a case report and brief review of literature
Giovanni Manfredi1, Andrea Solfanelli, Giorgia Dimitri
1NESMOS Department (Neurosciences, Mental Health and Sense Organs), and Unit of Psychiatry, Sant'Andrea Hospital, Sapienza University-Rome, School of Medicine and Psychology, Rome, Italy.
Abstract:
A Caucasian, male, young adult with recurrent agitated depression and suicidal ideation received lithium and oral olanzapine. His white blood cell count was normal at that time. Due to unsatisfactory response, he received 4 mg/day risperidone. While symptoms improved, leukopenia emerged, specifically directed towards neutrophils. Upon risperidone discontinuation, white blood cell count returned to reference values within 1 week. As symptom control was satisfactory, we attempted no risperidone rechallenge. Accurate blood testing must accompany atypical antipsychotic drug administration since blood dyscrasias are always possible with these drugs.
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