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A Syngeneic Murine Model of Endometriosis using Naturally Cycling Mice
Published on: November 24, 2020
Spontaneous endometriosis in a mandrill (Mandrillus sphinx)
1Laboratory of Comparative Pathology, Graduate School of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Journal of Comparative Pathology
|April 24, 2012
Summary
This study reports the first case of endometriosis in a mandrill. The condition involved ectopic endometrial tissue causing internal bleeding and organ adhesion.
Area of Science:
- Veterinary Pathology
- Primate Reproductive Health
Background:
- Endometriosis is a condition where endometrial tissue grows outside the uterus.
- It affects various mammalian species, but reports in non-human primates are rare.
Observation:
- A 25-year-old female mandrill presented with weakness, ascites, and internal bleeding.
- Gross examination revealed haemoperitoneum, peritoneal thickening, and uterine adhesions.
- Microscopic analysis confirmed ectopic endometrial tissue growth within and outside the uterus.
Findings:
- Ectopic endometrial tissue showed fibrosis and expressed CD10 and progesterone receptor.
- Glands within the ectopic tissue showed variable oestrogen receptor α expression.
- The diagnosis of endometriosis was confirmed through histological and immunohistochemical examination.
Implications:
- This case represents the first documented instance of naturally occurring endometriosis in a mandrill (Mandrillus sphinx).
- Understanding endometriosis in diverse primate species enhances comparative reproductive pathology knowledge.
- This finding may inform future research on primate reproductive health and disease.
