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Quantitation of Rabies Virus in Various Bovine Brain Structures
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Cerebral cryptococcomas in a cow.

G M Magalhães1, J P Elsen Saut, T Beninati

  • 1Faculdade de Medicina Veterinária, Universidade Federal de Uberlândia, Minas Gerais, Brasil.

Journal of Comparative Pathology
|April 24, 2012
PubMed
Summary
This summary is machine-generated.

A rare case of cerebral cryptococcomas, caused by Cryptococcus neoformans, was identified in a cow. This study details the pathological findings of these brain lesions in the absence of systemic infection.

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Area of Science:

  • Veterinary Pathology
  • Mycology
  • Neuropathology

Background:

  • Cryptococcomas are granulomatous lesions caused by Cryptococcus species.
  • Systemic cryptococcosis is more common in immunocompromised animals.
  • Cerebral involvement in bovine cryptococcosis is infrequently reported.

Purpose of the Study:

  • To describe a case of cerebral cryptococcomas in a cow.
  • To characterize the causative agent of the lesions.
  • To investigate the absence of systemic dissemination.

Main Methods:

  • Gross necropsy examination of the brain.
  • Histopathological examination of brain lesions.
  • Immunohistochemistry to identify the yeast species.

Main Results:

  • Two distinct cerebral cryptococcomas were identified grossly.
  • Microscopic analysis revealed yeast consistent with Cryptococcus neoformans.
  • Immunohistochemistry confirmed the isolate as Cryptococcus neoformans var. grubii.

Conclusions:

  • Cerebral cryptococcomas can occur in cattle without systemic signs of cryptococcosis.
  • Cryptococcus neoformans var. grubii is a causative agent of bovine cerebral cryptococcomas.
  • This case highlights the importance of neuropathological examination in diagnosing localized fungal infections.