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Related Experiment Video

Updated: May 23, 2026

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Co-Culture of Murine Small Intestine Epithelial Organoids with Innate Lymphoid Cells

Published on: March 23, 2022

Development and function of intestinal innate lymphoid cells.

M Cherrier¹, C Ohnmacht, S Cording

¹Institut Pasteur, Development of Lymphoid Tissues Unit, Paris 75724, France.

Current Opinion in Immunology

|April 24, 2012

Summary

This summary is machine-generated.

Innate lymphoid cells (ILCs) are crucial immune cells that lack antigen receptors. This review focuses on RORγt(+) ILCs and ILC2s, highlighting their roles in intestinal homeostasis and defense.

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Area of Science:

Immunology
Cell Biology

Background:

Innate lymphoid cells (ILCs) are lymphocytes lacking antigen receptors, encompassing Natural Killer (NK) cells and other subsets.
ILCs perform functions analogous to CD4(+) T helper cells, producing cytokines like IFNγ, IL-17, IL-22, and IL-13.
Unlike T cells, ILCs are not antigen-specific and respond rapidly to stimuli, playing key roles in early immune responses.

Purpose of the Study:

To review recent data on the development and function of ILCs.
To specifically examine the roles of RORγt(+) ILCs and ILC2s in the intestine.

Main Methods:

Literature review of recent scientific data.
Analysis of ILC development and function.

Main Results:

ILCs are essential for early responses to infection and injury.
ILCs contribute to maintaining homeostasis.
ILCs may regulate adaptive immunity.

Conclusions:

RORγt(+) ILCs and ILC2s are critical for intestinal homeostasis.
These ILC subsets play significant roles in intestinal defense mechanisms.