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04:32
Murine Oropharyngeal Aspiration Model of Ventilator-associated and Hospital-acquired Bacterial Pneumonia
Published on: June 28, 2018
Ventilator-associated sinusitis in adults: systematic review and meta-analysis
Michalis Agrafiotis1, Konstantinos Z Vardakas, Ioannis D Gkegkes
1Alfa Institute of Biomedical Sciences (AIBS), Athens, Greece.
Respiratory Medicine
|April 24, 2012
Summary
Ventilator-associated sinusitis (VAS) is common in critically ill patients, affecting 27% of those on mechanical ventilation. While linked to other infections, VAS does not appear to increase mortality risk.
Area of Science:
- Critical Care Medicine
- Infectious Diseases
- Epidemiology
Background:
- Ventilator-associated sinusitis (VAS) is a potential complication in mechanically ventilated patients.
- Understanding its prevalence, risk factors, and outcomes is crucial for patient management.
Purpose of the Study:
- To systematically review and meta-analyze data on the epidemiology, risk factors, treatment, and outcomes of VAS.
- To determine the association of VAS with other infections and mortality.
Main Methods:
- Systematic review and meta-analysis of 31 studies from 620 retrieved reports.
- Random effects model used to calculate pooled odds ratios (OR) and 95% confidence intervals (CIs).
Main Results:
- Infectious sinusitis affects 27% of mechanically ventilated patients and is a cause of fever in 25% of cases.
- Radiographic VAS is more common with nasotracheal intubation (OR 4.66). VAS is associated with ventilator-associated pneumonia (VAP) (OR 3.66) and bacteremia (OR 6.85).
- No significant association found between VAS and increased mortality (OR 1.02).
Conclusions:
- Ventilator-associated sinusitis is a frequent infection in critically ill adults.
- VAS is correlated with other significant infectious complications, but not directly with increased mortality.
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