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Updated: May 23, 2026

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Enhanced nitrite reductase activity associated with the haptoglobin complexed hemoglobin dimer: functional and

Camille J Roche1, David Dantsker, Abdu I Alayash

  • 1Department of Physiology and Biophysics, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

Nitric Oxide : Biology and Chemistry
|April 24, 2012
PubMed
Summary

Haptoglobin (Hp) binds cell-free hemoglobin (Hb), reducing its toxicity. This study shows Hp-bound Hb enhances nitric oxide production, offering a protective mechanism against circulating free Hb damage.

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