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Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...
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Clinical Applications of Epidermal Stem Cells

Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own EpiSCs...
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Acute Inflammation III: Local and Systemic Effects

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Inflammatory Response II: Inflammatory Exudate and Tissue Repair01:24

Inflammatory Response II: Inflammatory Exudate and Tissue Repair

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Related Experiment Video

Updated: May 23, 2026

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology
12:34

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

Published on: January 12, 2024

Eicosanoids in skin inflammation.

Anna Nicolaou1

  • 1School of Pharmacy and Centre for Skin Sciences, School of Life Sciences, University of Bradford, Richmond Road, Bradford BD7 1DP, UK. a.nicolaou@bradford.ac.uk

Prostaglandins, Leukotrienes, and Essential Fatty Acids
|April 24, 2012
PubMed
Summary

Eicosanoids are key to skin health and inflammation. Nutritional supplements like omega-3s and antioxidants may help manage skin conditions by influencing these compounds.

Area of Science:

  • Biochemistry
  • Dermatology
  • Nutrition Science

Background:

  • Eicosanoids are crucial for maintaining skin health and structural integrity.
  • They play a significant role in mediating inflammatory responses to environmental factors like UV radiation.
  • Eicosanoids are implicated in inflammatory and allergic skin disorders such as psoriasis and atopic dermatitis.

Purpose of the Study:

  • To review the biochemical aspects of cutaneous eicosanoid metabolism.
  • To elucidate the role of eicosanoids in skin inflammation and related conditions.
  • To explore the potential of nutritional supplementation with specific bioactives for skin health.

Main Methods:

  • Literature review focusing on biochemical pathways of eicosanoid metabolism in the skin.

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Last Updated: May 23, 2026

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology
12:34

The Efficacy and Underlying Pathway Mechanisms of ShiDuGao Treatment for Anus Eczema Based on GEO Datasets and Network Pharmacology

Published on: January 12, 2024

  • Analysis of the contribution of eicosanoids to inflammatory skin conditions.
  • Evaluation of research on nutritional interventions for skin health.

    • Main Results:

    • Eicosanoid metabolism is central to skin homeostasis and inflammatory processes.
    • UV radiation and conditions like psoriasis and atopic dermatitis involve eicosanoid mediation.
    • Nutritional supplementation with omega-3, omega-6 fatty acids, and antioxidants shows promise.

    Conclusions:

    • Understanding cutaneous eicosanoid metabolism is vital for addressing skin health issues.
    • Targeting eicosanoid pathways through nutrition offers a potential therapeutic strategy.
    • Bioactive compounds like omega-3s, omega-6s, and antioxidants are important for skin health management.