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Related Concept Videos

The Cell Cycle Control System01:28

The Cell Cycle Control System

The cell cycle regulation directs how a cell proceeds from one phase to the next and begins mitosis. The cell cycle control system includes intracellular regulatory molecules and external triggers. They provide "stop" or "advance" signals and operate at specific cell cycle stages termed checkpoints to ensure that a particular process is completed before the cell advances to the next phase.
Cyclins and cyclin-dependent kinases (Cdks) are the primary cell cycle regulators and function at the cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
The Cell Cycle Control System02:11

The Cell Cycle Control System

The cell cycle is an organized set of events that leads the cell to divide into two daughter cells, each containing chromosomes identical to the parent cell. It is the cell cycle that leads to the formation of an entire organism from a single-cell zygote. Besides, cell division also functions in the renewal or repair of tissues in adult multicellular eukaryotes. For example, in the bone marrow, the stem cells divide to form new blood cells. Although essential for several functions, cell...
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
Anaphase Promoting Complex00:50

Anaphase Promoting Complex

The stepwise destruction of specific proteins is necessary for the progression and completion of the cell cycle. Such proteins are ubiquitinated by ubiquitin ligases and then subsequently destroyed by the proteasome. The SCF (Skp1/Cullin/F-box) and the anaphase-promoting complex (APC) are two important ubiquitin ligases involved in cell cycle progression. While SCF is active throughout the cell cycle, APC gets activated during metaphase to anaphase transition. Cdc20 or Cdh1 binds to APC and...
Inhibition of Cdk Activity02:34

Inhibition of Cdk Activity

The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...

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Related Experiment Video

Updated: May 23, 2026

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
12:02

Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols

Published on: June 6, 2017

Cell cycle control by anchorage signaling.

Hiroto Okayama1

  • 1Department of Biochemistry and Molecular Biology, Faculty and Graduate School of Medicine, The University of Tokyo, Tokyo, Japan. okayama@m.u-tokyo.ac.jp

Cellular Signalling
|April 24, 2012
PubMed
Summary
This summary is machine-generated.

Normal cells need extracellular matrix anchorage to survive and proliferate. Cancer cells lose this requirement, enabling tumor growth and metastasis, a key area of cell cycle and cell death research.

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Studying Cell Cycle-regulated Gene Expression by Two Complementary Cell Synchronization Protocols
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Analysis of Cell Cycle Position in Mammalian Cells
12:19

Analysis of Cell Cycle Position in Mammalian Cells

Published on: January 21, 2012

Area of Science:

  • Cell Biology
  • Cancer Biology
  • Biochemistry

Background:

  • Cellular anchorage to the extracellular matrix is essential for normal cell proliferation and survival.
  • Loss of anchorage triggers apoptosis, a process known as anoikis, in non-transformed cells.
  • Malignant transformation allows cells to bypass anchorage dependence, contributing to tumorigenesis and metastasis.

Purpose of the Study:

  • To review recent critical findings in anchorage signaling.
  • To explore the mechanisms controlling cell cycle progression and cell death via anchorage signaling.
  • To present a new perspective on cell cycle and cell death regulation.

Main Methods:

  • Literature review of recent advancements in anchorage signaling research.
  • Analysis of studies investigating the link between anchorage, cell cycle, and apoptosis.
  • Synthesis of emerging concepts in cell cycle and cell death regulation.

Main Results:

  • Significant progress has been made in understanding anchorage signaling pathways.
  • New insights reveal how anchorage influences G(1)-S cell cycle transition.
  • The role of anchorage in preventing anoikis in cancer cells is being elucidated.

Conclusions:

  • Anchorage signaling is a critical regulator of cell cycle progression and apoptosis.
  • Understanding these mechanisms offers potential therapeutic targets for cancer.
  • Recent findings are reshaping our perspective on cell survival and death regulation.